Protective Effect of Fraction of Azadirachta Indica Leaf Extract on Carbon Tetrachloride Induced Hepatotoxicity

نویسندگان

  • Pulok K. Mukherjee
  • Tejendra Bhakta
  • B.P. Saha
  • S. Pal
  • M. Pal
  • Achintya A.K. Das
چکیده

The hepatoprotective activity of a fraction of the leaf extract of A.indica against carbon tetrachloride : liquid paraffin (1:1) induced liver damage in rats at doses of 100 mg/kg and 200 mg/kg was evaluated. A significant dose dependent hepatoprotective activity was evidenced by lowering of the elevated levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) in the serum of CCl(4) : liquid paraffin (1:1) treated rats.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective Effect of Ricinus communis Leaves Extract on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

       Ricinus communis Linn. (Euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. In the Indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a lo...

متن کامل

The Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Rats

Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous ...

متن کامل

Hepatoprotective Effect of Ficus carica Leaf Extract on Mice Intoxicated with Carbon Tetrachloride

Protective action of Ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4). Male albino mice were divided into six groups. group I was normal control group; group II received olive oil (CCl4 solvent), groups III-VI received CCl4. After inducing hepatic damage, group III served as control for CCl4; a...

متن کامل

Hepatoprotective Effect of Ficus carica Leaf Extract on Mice Intoxicated with Carbon Tetrachloride

Protective action of Ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4). Male albino mice were divided into six groups. group I was normal control group; group II received olive oil (CCl4 solvent), groups III-VI received CCl4. After inducing hepatic damage, group III served as control for CCl4; a...

متن کامل

Protective Effect of Berberis integerrima Fruit Extract on Carbon-Tetrachloride Induced Hepatotoxicity in Rats

Background & Objective: Hepatoprotective effect of antioxidants such as flavnoids has been demonstrated. The aim of the present study was to assess the hepatoprotective effect of the methanolic extract of Berberis integerrima fruit (MEBIF) on carbon-tetrachloride (CCL4) induced hepatotoxicity in rats. Materials & Methods: Forty male rats were divided into 5 groups as follows: 1) normal, 2) toxi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 1994